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Certain peptides, like BPC-157, can cross the blood-brain barrier when administered nasally, allowing them to interact with neurotransmitters and reduce inflammation in the nervous system
Stacking them is physiologically redundant in part: tesamorelin raises endogenous GH and downstream IGF-1, while IGF-1 LR3 adds direct IGF-1R stimulation on top
Based on these associations, cerebrovascular reactivity may relate to early cerebrovascular dysfunction associated with neurodegenerative diseases like ADRD
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These differences, rather than the drug itself, could account for a portion of the observed risk reduction
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